The effects of claudin 14 during early Wallerian degeneration after sciatic nerve injury
Leilei Gong
Yun Zhu
Xi Xu
Huaiqin Li
Weimin Guo
Qin Zhao
Dengbing Yao
摘要：Claudin 14 has been shown to promote nerve repair and regeneration in the early stages of Wallerian degeneration (0–4 days) in rats with sciatic nerve injury, but the mechanism under-lying this process remains poorly understood. This study reported the effects of claudin 14 on nerve degeneration and regeneration during early Wallerian degeneration. Claudin 14 expression was up-regulated in sciatic nerve 4 days after Wallerian degeneration. The altered expression of claudin 14 in Schwann cells resulted in expression changes of cytokines in vitro. Expression of claudin 14 affected c-Jun, but not Akt and ERK1/2 pathways. Further studies revealed that enhanced expression of claudin 14 could promote Schwann cell proliferation and migration. Silencing of claudin 14 expression resulted in Schwann cell apoptosis and reduction in Schwann cell proliferation. Our data revealed the role of claudin 14 in early Wallerian degeneration, which may provide new insights into the molecular mechanisms of Wallerian degeneration.
机标关键词：nerve injuryWallerian degenerationcell proliferationsciatic nervemolecular mechanismscell apoptosisSchwann cellsnerve repair
资助基金：This research was supported by grants from the National Natural Science Foundation of China, Grant (No.81370982,31170946, Key Program, Grant No.81130080)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 2151-2158 )
英文信息