Thermomineral water promotes axonal sprouting but does not reduce glial scar formation in a mouse model of spinal cord injur y
Dubravka Aleksi
Milan Aksi
Nevena Divac
Vidosava Radonji
Branislav Filipovi
Igor Jakovevski
摘要：Thermomineral water from the Atomic Spa Gornja Trep?a has been used for a century in the treatment of neurologic disease. The thermomineral water contains microelements, including lithium and magnesium, which show neural regeneration-promoting effects after central nervous system injury. In this study, we investigated the effects of oral intake of thermomineral water from the Atomic Spa Gornja Trep?a on nerve regeneration in a 3-month-old mouse model of spinal cord injury. The mice receiving oral intake of thermomineral water showed better locomo-tor recovery than those without administration of thermomineral water at 8 and 12 weeks after lower thoracic spinal cord compression. At 12 weeks after injury, sprouting of catecholaminergic axons was better in mice that drank thermomineral water than in those without administration of thermomineral water, but there was no difference in glial reaction to injury between mice with and without administration of thermomineral water. These ifndings suggest that thermomineral water can promote the nerve regeneration but cannot reduce glial scar formation in a mouse model of spinal cord injury.
机标关键词：spinal cord injurynerve regenerationmouse modelcentral nervous system
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 2174-2181 )
英文信息