Melatonin lowers edema after spinal cord injur y
Cheng Li
Xiao Chen
Suchi Qiao
Xinwei Liu
Chang Liu
Degang Zhu
Jiacan Su
Zhiwei Wang
摘要：Melatonin has been shown to diminish edema in rats. Melatonin can be used to treat spinal cord injury. This study presumed that melatonin could relieve spinal cord edema and examined how it might act. Our experiments found that melatonin (100 mg/kg, i.p.) could reduce the water content of the spinal cord, and suppress the expression of aquaporin-4 and glial ifbrillary acidic protein after spinal cord injury. This suggests that the mechanism by which melatonin alleviates the damage to the spinal cord by edema might be related to the expression of aquaporin-4 and glial ifbrillary acidic protein.
机标关键词：spinal cord injuryacidic proteinwater content
资助基金：This study was supported by the China Postdoctoral Science Foundation Grant, (No.2014M552692)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 2205-2210 )
英文信息