Fat cell-secreted adiponectin mediates physical exercise-induced hippocampal neurogenesis:an alternative anti-depressive treatment?
Suk Yu Yau
Ang Li
Aimin Xu
Kwok-fai So
摘要：Psychological depression is drawing accumulating attention nowadays, due to the skyrocketing incidence worldwide and the enormous burdens it incurs. Physical exercise has been long recog-nized for its therapeutic effects on depressive disorders, although knowledge of the underlying mechanisms remains limited. Suppressed hippocampal neurogenesis in adult brains has been regarded, at least partly, contributive to depression, whereas physical exercise that restores neuro-genesis accordingly exerts the anti-depressive action. Several recent publications have suggested the potential role of adiponectin, a protein hormone secreted by peripheral mature adipocytes, in mediating physical exercise-triggered enhancement of hippocampal neurogenesis and alleviation of depression. Here, we brielfy review these novel ifndings and discuss the possibility of counter-acting depression by modulating adiponectin signaling in the hippocampus with interventions including physical exercise and administration of pharmacological agents.
机标关键词：
资助基金：Programme of Introducing Talents of Discipline to Uni-versities(B14036)Project of International, as well as Hong Kong, Macao& Taiwan Science and Technology Cooperation Innovation Platform in Universities in Guangdong Province, China (2013gjhz0002)
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 7-9 )
英文信息