Large animal models of human cauda equina injury and repair：evaluation of a novel goat model
Wen-tao Chen
Pei-xun Zhang
Feng Xue
Xiao-feng Yin
Cao-yuan Qi
Jun Ma
Bo Chen
You-lai Yu
Jiu-xu Deng
Bao-guo Jiang
摘要：Previous animal studies of cauda equina injury have primarily used rat models, which display signiifcant differences from humans. Furthermore, most studies have focused on electrophysio-logical examination. To better mimic the outcome after surgical repair of cauda equina injury, a novel animal model was established in the goat. Electrophysiological, histological and magnetic resonance imaging methods were used to evaluate the morphological and functional outcome after cauda equina injury and end-to-end suture. Our results demonstrate successful establish-ment of the goat experimental model of cauda equina injury. This novel model can provide detailed information on the nerve regenerative process following surgical repair of cauda equina injury.
机标关键词：
资助基金：Program for Innovative Research Team in Uni-versity of Ministry of Education of China, (No. IRT1201)the National Natural Science Foundation of China, (No.31271284,31171150,81171146,30971526,31040043,31371210,81372044,31471144)Program for New Century Excellent Talents in University of Ministry of Education of China, (No. BMU20110270)the Natural Science Foundation of Beijing of China, (No.7142164)
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 60-64 )
英文信息