Biological conduit small gap sleeve bridging method for peripheral nerve injury：regeneration law of nerve ifbers in the conduit
Pei-xun Zhang
Li-ya A
Yu-hui Kou
Xiao-feng Yin
Feng Xue#
Na Han
Tian-bing Wang
Bao-guo Jiang
摘要：The clinical effects of 2-mm small gap sleeve bridging of the biological conduit to repair periph-eral nerve injury are better than in the traditional epineurium suture, so it is possible to replace the epineurium suture in the treatment of peripheral nerve injury. This study sought to identify the regeneration law of nerve fibers in the biological conduit. A nerve regeneration chamber was constructed in models of sciatic nerve injury using 2-mm small gap sleeve bridging of a biodegradable biological conduit. The results showed that the biological conduit had good his-tocompatibility. Tissue and cell apoptosis in the conduit apparently lessened, and regenerating nerve ifbers were common. The degeneration regeneration law of Schwann cells and axons in the conduit was quite different from that in traditional epineurium suture. During the prime period for nerve fiber regeneration (2–8 weeks), the number of Schwann cells and nerve fibers was higher in both proximal and distal ends, and the effects of the small gap sleeve bridging method were better than those of the traditional epineurium suture. The above results provide an objec-tive and reliable theoretical basis for the clinical application of the biological conduit small gap sleeve bridging method to repair peripheral nerve injury.
机标关键词：
资助基金：Program for Innovative Research Team in University of Ministry of Education of China, (No. IRT1201)the National Natural Science Founda-tion of China, (No.31271284,31171150,81171146,30971526,31100860,31040043,31371210)Program for New Century Excellent Talents in University of Ministry of Education of China, (No. BMU20110270)
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 71-78 )
英文信息