Inhibition of inlfammatory cytokines after early decompression may mediate recovery of neurological function in rats with spinal cord injury
Jia-bing Xie
Xin Zhang
Quan-hui Li
Zhu-jun Xu
摘要：A variety of inlfammatory cytokines are involved in spinal cord injury and inlfuence the recov-ery of neuronal function. In the present study, we established a rat model of acute spinal cord injury by cerclage. The cerclage suture was released 8 or 72 hours later, to simulate decompres-sion surgery. Neurological function was evaluated behaviorally for 3 weeks after surgery, and tumor necrosis factorα immunoreactivity and apoptosis were quantiifed in the region of injury. Rats that underwent decompression surgery had significantly weaker immunoreactivity of tumor necrosis factorα and signiifcantly fewer apoptotic cells, and showed faster improvement of locomotor function than animals in which decompression surgery was not performed. De-compression at 8 hours resulted in signiifcantly faster recovery than that at 72 hours. These data indicate that early decompression may improve neurological function after spinal cord injury by inhibiting the expression of tumor necrosis factorα.
机标关键词：tumor necrosis factorspinal cord injuryrat model
资助基金：Funding(No.09C33)a grant from the Key Scientific Research Project of Cultivating Fund of Wannan Medical College in China, (No. WK2014ZF14)
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 219-224 )
英文信息