Electroacupuncture improves microcirculation and neuronal morphology in the spinal cord of a rat model of intervertebral disc extrusion
Dai-xun Jiang
Zhi-song Lu
Ge-bin Li
Sheng-yong Sun
Xiang Mu
Peter Lee
Wu Chen
摘要：Most studies on spinal cord neuronal injury have focused on spinal cord tissue histology and the expression of nerve cell damage and repair-related genes. The importance of the microcirculation is often ignored in spinal cord injury and repair research. Therefore, in this study, we established a rat model of intervertebral disc extrusion by inserting a silica gel pad into the left ventral sur-face of T13. Electroacupuncture was used to stimulate the bilateralZusanlipoint (ST36) and Neiting point (ST44) for 14 days. Compared with control animals, blood lfow in the ifrst lumbar vertebra (L1) was noticeably increased in rats given electroacupuncture. Microvessel density in the T13 segment of the spinal cord was increased significantly as well. The number of normal neurons was higher in the ventral horn of the spinal cord. In addition, vacuolation in the white matter was lessened. No obvious glial cell proliferation was visible. Furthermore, hindlimb motor function was improved signiifcantly. Collectively, our results suggest that electroacupuncture can improve neuronal morphology and microcirculation, and promote the recovery of neurological functions in a rat model of intervertebral disc extrusion.
机标关键词：intervertebral discrat modelspinal cord injurycell proliferationneuronal injurylumbar vertebramotor functionventral horn
资助基金：This study was supported by the National Natural Science Foundation of China, (No.31372473,30871886)the Funding Project for Academic Human Resources Development in Institutions of Higher Learning under the Jurisdiction of Beijing Municipality of China, (No. PHR201107134)the 2012 Scientific Research Quality Raising Funds of Beijing University of Agricul-ture of China, (No. PXM2012_014207_000010)
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 237-243 )
英文信息