Ethanol extract ofOenanthe javanica increases cell proliferation and neuroblast differentiation in the adolescent rat dentate gyrus
Bai Hui Chen
Joon Ha Park
Jeong Hwi Cho
In Hye Kim
Bich Na Shin
Ji Hyeon Ahn
Seok Joon Hwang
Bing Chun Yan
Hyun Jin Tae
Jae Chul Lee
Eun Joo Bae
Yun Lyul Lee
Jong Dai Kim
Moo-Ho Won
Il Jun Kang
摘要：Oenanthe javanica is an aquatic perennial herb that belongs to theOenanthe genus in Apiaceae family, and it displays well-known medicinal properties such as protective effects against glu-tamate-induced neurotoxicity. However, few studies regarding effects ofOenanthe javanica on neurogenesis in the brain have been reported. In this study, we examined the effects of a normal diet and a diet containing ethanol extract ofOenanthe javanica on cell proliferation and neu-roblast differentiation in the subgranular zone of the hippocampal dentate gyrus of adolescent rats using Ki-67 (an endogenous marker for cell proliferation) and doublecortin (a marker for neuroblast). Our results showed thatOenanthe javanica extract signiifcantly increased the number of Ki-67-immunoreactive cells and doublecortin-immunoreactive neuroblasts in the subgranular zone of the dentate gyrus in the adolescent rats. In addition, the immunoreactivity of brain-derived neurotrophic factor was signiifcantly increased in the dentate gyrus of theOe-nanthe javanica extract-treated group compared with the control group. However, we did not ifnd that vascular endothelial growth factor expression was increased in theOenanthe javanica extract-treated group compared with the control group. These results indicate thatOenanthe javanica extract improves cell proliferation and neuroblast differentiation by increasing brain-de-rived neurotrophic factor immunoreactivity in the rat dentate gyrus.
机标关键词：dentate gyruscell proliferationneurotrophic factorgrowth factor expressionprotective effects
资助基金：Funding(No. HRF-S-12)
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 271-276 )
英文信息