electrical stimulation of the vagus nerve protects against cerebral ischemic injury through an anti-inlfammatory mechanism
Yao-xian Xiang
Wen-xin Wang
Zhe Xue
Lei Zhu
Sheng-bao Wang
Zheng-hui Sun
摘要：Vagus nerve stimulation exerts protective effects against ischemic brain injury; however, the underlying mechanisms remain unclear. In this study, a rat model of focal cerebral ischemia was established using the occlusion method, and the right vagus nerve was given electrical stimula-tion (constant current of 0.5 mA; pulse width, 0.5 ms; frequency, 20 Hz; duration, 30 seconds; every 5 minutes for a total of 60 minutes) 30 minutes, 12 hours, and 1, 2, 3, 7 and 14 days after surgery. Electrical stimulation of the vagus nerve substantially reduced infarct volume, improved neurological function, and decreased the expression levels of tumor necrosis factor-α and in-terleukin-6 in rats with focal cerebral ischemia. The experimental findings indicate that the neuroprotective effect of vagus nerve stimulation following cerebral ischemia may be associated with the inhibition of tumor necrosis factor-α and interleukin-6 expression.
机标关键词：focal cerebral ischemiavagus nerve stimulationneuroprotective effectischemic brain injuryprotective effectsrat model
资助基金：This study was supported by the Beijing Natural Science Foundation of China, (No.7122164)
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 576-582 )
英文信息