Curcumin and Apigenin - novel and promising therapeutics against chronic neuroinlfammation in Alzheimer’s disease
Madhuri Venigalla
Erika Gyengesi
Gerald Mnch
摘要：Alzheimer’s disease is a progressive neurodegenerative disorder, characterized by deposition of amyloid beta, neuroifbrillary tangles, astrogliosis and microgliosis, leading to neuronal dys-function and loss in the brain. Current treatments for Alzheimer’s disease primarily focus on enhancement of cholinergic transmission. However, these treatments are only symptomatic, and no disease-modifying drug is available for Alzheimer’s disease patients. This review will provide an overview of the proven antioxidant, anti-inlfammatory, anti-amyloidogenic, neuroprotective, and cognition-enhancing effects of curcumin and apigenin and discuss the potential of these compounds for Alzheimer’s disease prevention and treatment. We suggest that these compounds might delay the onset of Alzheimer’s disease or slow down its progression, and they should enter clinical trials as soon as possible.
机标关键词：neurodegenerative disorderprevention and treatmentclinical trialsslow down
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 1181-1185 )
英文信息