Neuroinlfammation and comorbidities are frequently ignored factors in CNS pathology
Raluca Elena Sandu
Ana Maria Buga
Adriana Uzoni
Eugen Bogdan Petcu
Aurel Popa-Wagner
摘要：Virtually all drug interventions that have been successful pre-clinically in experimental stroke have failed to prove their efifcacy in a clinical setting. This could be partly explained by the complexity and heterogeneity of human diseases as well as the associated co-morbidities which may render neuroprotective drugs less efifcacious in clinical practice. One aspect of crucial importance in the physiopathology of stroke which is not completely understood is neuroinlfammation. At the pres-ent time, it is becoming evident that subtle, but continuous neuroinlfammation can provide the ground for disorders such as cerebral small vessel disease. Moreover, advanced aging and a number of highly prevalent risk factors such as obesity, hypertension, diabetes and atherosclerosis could act as “silent contributors” promoting a chronic proinlfammatory state. This could aggravate the out-come of various pathological entities and can contribute to a number of subsequent post-stroke complications such as dementia, depression and neurodegeneration creating a pathological vicious cycle. Moreover, recent data suggests that the inlfammatory process might be closely linked with multiple neurodegenerative pathways related to depression. In addition, pro-inlfammatory cyto-kines could play a central role in the pathophysiology of both depression and dementia.
机标关键词：clinical practicerisk factors
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 1349-1355 )
英文信息