PTEN inhibition and axon regeneration and neural repair
Yosuke Ohtake
Umar Hayat
Shuxin Li
摘要：The intrinsic growth ability of all the neurons declines during development although some may grow better than others. Numerous intracellular signaling proteins and transcription factors have been shown to regulate the intrinsic growth capacity in mature neurons. Among them, PI3 kinase/Akt pathway is important for controlling axon elongation. As a negative regulator of this pathway, the tumor suppressor phosphatase and tensin homolog (PTEN) appears critical to con-trol the regenerative ability of young and adult neurons. This review will focus on recent research progress in axon regeneration and neural repair by PTEN inhibition and therapeutic potential of blocking this phosphatase for neurological disorders. Inhibition of PTEN by deletion in con-ditional knockout mice, knockdown by short-hairpin RNA, or blockade by pharmacological approaches, including administration of selective PTEN antagonist peptides, stimulates various degrees of axon regrowth in juvenile or adult rodents with central nervous system injuries. Im-portantly, post-injury PTEN suppression could enhance axonal growth and functional recovery in adult central nervous system after injury.
机标关键词：central nervous systemrecent research progressneurological disorderstranscription factorstherapeutic potentialaxon regenerationtumor suppressortensin homolog
资助基金：Funding(1R21NS066114)Funding(1R01NS079432 and 1R01EY024575)Christopher& Dana Reeve Foundation(LA1-1002-2)Shriners Research Foundation(86300)
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 1363-1368 )
英文信息