Neuroprotection and recovery from early-life adversity: considerations for environmental enrichment
Amanda C.Kentner
摘要：In the laboratory,environmental enrichment (EE) is used as a protocol to understand the functional,behavioral and molecular mechanisms that underlie neural plasticity (van Praag et al.,2000;Sale et al.,2014).In addition,it is utilized to provide supplementary resources to animals in order to maintain their well-being and to preserve the scientific validity of the study at hand (see is designed using a multifactorial approach incorporating novelty (e.g.,alternating toys and locations of objects within the cage) alongside opportunities for physical activity (e.g.,increased cage space,running wheels) and social engagement facilitated through group housing;see Figure 1.Such refinement of animal housing conditions can reduce stress and stereotyped behaviors (e.g.,bar-biting,trichotillomania),that may interfere with research endpoints,by decreasing boredom and promoting species typical behaviors such as foraging,burrowing and exploration (Simpson and Kelly,2011).
机标关键词：molecular mechanismsphysical activityneural plasticityin order
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 1545-1547 )
英文信息