The emerging roles of transplanted radial glial cells in regenerating the central nervous system
Robin E.White
Denis S.Barry
摘要：Scientists conclude that a combination of treatments involving rehabilitation,drug delivery,surgery and cell transplantation are necessary to achieve significant progress in regenerating the injured central nervous system (CNS).The benefits of pluripotent stem cells in neurodegenerative disorders are well recognised (Thompson and Bjorklund,2015) and cell culture methods have advanced to condition and enrich cells of therapeutic interest,thereby optimising their assimilation into diseased CNS regions.Radial glial cells are a unique cell type that act as both cell progenitors and scaffolds during development,orchestrating many brain and spinal cord formation events.In light of new developments elucidating their precursor and regenerative capacities,we will place a spot light on the transplantation potentials of embryonic stem (ES) cell or cell line derived radial glia and endogenous radial glial cell populations in re-establishing neural connectivity and restoring cell populations following neurodegeneration.
机标关键词：neurodegenerative disorderscentral nervous systemcell transplantationcell culturespinal cordstem cellsglial cellcell line
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 1548-1551 )
英文信息