Old dogs with new tricks: intra-axonal translation of nuclear proteins
Jeffery L.Twiss
Tanuja T.Merianda
摘要：Many different types of polarized eukaryotic cells have been shown to segregate synthesis for some protein subpopulations to cytoplasmic domains distant from their nucleus.For neurons,these distances can be tens-to-thousands fold more than the diameter of the cell body.Both axons and dendrites make use of this localized protein synthesis to bring autonomy to these far reaches of the cytoplasm (Gomes et al.,2014).This local mRNA translation is often used to mount a rapid response to extracellular stimuli encountered by the distal axon and dendrite.Indeed,activating translation of mRNAs residing locally at the synapse or growth cone brings a much more rapid response than could be achieved by transporting new proteins from the cell body.The neuron likely reaps a cost benefit from this mechanism in terms of energy consumption,since multiple protein copies can be generated from a single mRNA through sequential rounds of translation.Localized protein synthesis could also more effectively position a protein near its site of action or even bring an unanticipated novel function to the protein.
机标关键词：protein synthesisrapid responseenergy consumption
资助基金：Work on axonal translation in the Twiss lab is supported by funds from National Institutes of Health(P01-NS055976 and R01-NS041596)National Science Foundation(MCB-1020970)Dr Miriam and Sheldon G.Adelson Medical Research Foundation, and the Department of Defense/US Army Medical Research and Development(OR120042)
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 1560-1562 )
英文信息