Insights of the brain damage response using antibodies identifying surface antigens on neural stem cells and neuroblasts
Silvia Santamaria
Jose A.Garcia-Sanz
摘要：Similarly to other adult tissues,a hierarchical structure has been established for the brain,where the differentiated cell types (neurons,oligodendrocytes and astrocytes) are generated from primary progenitor cells,known as type B astrocytes or neural stem cells (NSC),through one or multiple stages of amplification (transient amplifying cells) that generate precursor cells (iPC) with more restricted potential nIPCs (neural),aIPCs (astrocytes),oIPC (oligodendrocytes) (Kriegstein and Alvarez-Buylla,2009).In the adult rodent brain,NSCs and iPCs are mainly restricted to the niches on the subventricular zone (SVZ) of the lateral ventricles (Doetsch et al.,1999;Kriegstein and Alvarez-Buylla,2009).This hierarchical structure of the brain is critical for the understanding of brain development and adult neurogenesis,to develop new strategies for brain repair,or for the understanding of brain tumor development.
机标关键词：neural stem cellshierarchical structuresubventricular zoneprogenitor cellsbrain tumor
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1574-1575 )
英文信息