Glypican 4 down-regulation in pluripotent stem cells as a potential strategy to improve differentiation and to impair tumorigenicity of cell transplants
Rosanna Dono
摘要：Recent advances in stem cell technologies have opened new avenues for the treatment of a number of diseases still lacking effective therapeutic options.Cell transplantation has emerged as among the most promising clinical intervention for disorders such as injuries,diabetes,liver diseases,neurodegeneration and heart failure (Lee et al.,2013;Forbes and Rosenthal,2014;Tabar and Studer,2014).To date much attention is given to the potential application of human pluripotent stem cells (hPSCs) including both embryonic (hESCs) and induced pluripotent stem cells (hiPSCs) for regenerative medicine (Yamanaka,2012;Lee et al.,2013;Tabar and Studer,2014).Owing to their remarkable ability to self-renewal indefinitely and to differentiate into all mature cell types hPSCs appear of great advantage to generate an unlimited number of disease-relevant cells.
机标关键词：potential applicationstem cellsheart failure
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1576-1577 )
英文信息