Transforming growth factor β1-mediated anti-inflammation slows progression of midbrain dopaminergic neurodegeneration in Parkinson's disease?
Bj(o)rn Spittau
摘要：Parkinson's disease (PD) is characterized by the progressive loss of midbrain dopaminergic (mDA) neurons and a subsequent decrease in striatal dopamine levels,which cause the typical clinical motor symptoms such as muscle rigidity,bradykinesia and tremor.Although a subset of PD cases has been described to arise from inherited mutations of genes such as α-Synuclein or Lrkk2,the majority of PD cases develop spontaneously.Despite intensive research,the molecular mechanisms underlying degeneration of mDA neurons are only poorly understood.
机标关键词：molecular mechanisms
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 1578-1580 )
英文信息