Studying neurological disorders using induced pluripotent stem cells and optogenetics
Eunice W.M.Chin
Eyleen L.K.Goh
摘要：Neurological disorders are amongst the most widely studied human aliments.Yet,they are also one of the most poorly understood.Although most of these disorders are polygenic,genotype still plays an important role in their etiologies.For example,in schizophrenia and autism spectrum disorders,there is a 40-60％ concordance rate in monozygotic twins,with 60-90％ heritability (Burmeister et al.,2008).However,the mechanisms by which multiple genes and their genomic variations influence the phenotypes of the disorders remain to be understood.The complexities of the disorders are further compounded by the individual rarity of the genomic variations and their variable penetrance (Cook and Scherer,2008).Thus,conventional disease modeling,such as gene knockout in cells or in animals,to attain the desired disease genotype may not be the most suitable platform for tackling most neurological disorders.
机标关键词：stem cellsneurological disordersgene knockout
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 1720-1722 )
英文信息