Immunization with Cop-1 promotes neuroprotection and neurogenesis after ischemic stroke
Yolanda Cruz
Paola Suárez-Meade
Antonio Ibarra
摘要：Cerebrovascular diseases are considered to be amongst the most serious public health issues,since they are the third leading cause of death (WHO,2014) and the most common cause of disability worldwide.Its monetary significance is evidenced by the economic burden imposed on health care systems,given that the cost of medical care for a patient that has suffered a stroke is around $25,741 US dollars every 5 years (Luengo-Fernandez et al.,2012).A stroke occurs as a result of a disturbance or interruption of cerebral blood flow that significantly reduces the supply of oxygen and glucose to the neural tissue.Consequently,several cell death mechanisms (secondary lesion mechanisms) such as necrosis,excitotoxicity,free radical production and inflammation are triggered (Castillo,2000).Over the last decades,a variety of therapies with thrombolytic,neuroprotective,and restorative properties have been investigated.
机标关键词：cerebral blood flowcause of deathas a result ofpublic healthhealth carecell death
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1733-1734 )
英文信息