Novel approaches for the development of peripheral nerve regenerative therapies
Felix Beyer
Patrick Küry
摘要：Schwann cells are the myelinating glial cells of the peripheral nervous system (PNS).By establishing lipid-rich myelin sheaths around large-caliber axons,they ensure that electrical signal transmission is accelerated-a process referred to as saltatory signal propagation.Apart from this prominent physiological function,these cells also exert important pathophysiological roles in PNS injuries or diseases.In contrast to the central nervous system (CNS),the adult PNS retains a remarkably high degree of intrinsic regeneration.As a consequence,transected axons and damaged myelin sheaths can be repaired and nerve functionality can be restored.This spontaneous regenerative capacity depends on (inter) actions of macrophages,neurons,and Schwann cells.
机标关键词：central nervous systemSchwann cellsphysiological functionsignal transmission
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 1743-1745 )
英文信息