The progress in optic nerve regeneration, where are we?
Jennifer Wei Huen Shum
Kwok-fai So
摘要：Optic nerve regeneration is an important area of research. It can be used to treat patients suffering from optic neuropathy and provides insights into the treatment of numerous neurodegenerative diseases. There are many hurdles impeding optic regeneration in mammals. The mammalian central nervous system is non-permissive to regeneration and intrinsically lacks the capacity for axonal regrowth. Any axonal injury also triggers a vicious cycle of apoptosis. Understanding these hurdles provides us with a rough framework to appreciate the essential steps to bring about optic nerve regeneration: enhancing neuronal survival, axon regeneration, remyelination and establishing functional synapses to the original neuronal targets. In this review article, we will go through current potential treatments for optic nerve regeneration, which includes neurotrophic factor provision, inlfammatory stimulation, growth inhibition suppression, intracellular sig-naling modiifcation and modeling of bridging substrates.
机标关键词：nerve regenerationneurodegenerative diseasescentral nervous systemneurotrophic factor
资助基金：The work is supported by National Program on Key Basic Research Project of China(973 Program)The work is supported by National Program on Key Basic Research Project of China(2011CB707501)Program of Introducing Talents of Discipline to Universities(B14036)
论文发表日期：2016-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 32-36 )
英文信息