Unmasking the responses of the stem cells and progenitors in the subventricular zone after neonatal and pediatric brain injuries
Mariano Guardia Clausi
Ekta Kumari
Steven W.Levison
摘要：There is great interest in the regenerative potential of the neural stem cells and progenitors that populate the subventricular zone (SVZ). However, a comprehensive understanding of SVZ cell responses to brain in-juries has been hindered by the lack of sensitive approaches to study the cellular composition of this niche. Here we review progress being made in deciphering the cells of the SVZ gleaned from the use of a recently designed lfow cytometry panel that allows SVZ cells to be parsed into multiple subsets of progenitors as well as putative stem cells. We review how this approach has begun to unmask both the heterogeneity of SVZ cells as well as the dynamic shifts in cell populations with neonatal and pediatric brain injuries. We also discuss how lfow cytometric analyses also have begun to reveal how speciifc cytokines, such as Leuke-mia inhibitory factor are coordinating SVZ responses to injury.
机标关键词：brain injuriessubventricular zoneneural stem cells
论文发表日期：2016-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 45-48 )
英文信息