Considering calcium-binding proteins in invertebrates: multi-functional proteins that shape neuronal growth
Charles R.Tessier
摘要：Calcium is a critical second messenger molecule in all cells and is vital in neurons for synaptic transmission.Given this importance,calcium ions are tightly controlled by a host of molecular players including ion channels,sensors,and buffering proteins.Calcium can act directly by binding to signaling molecules or calcium's effects can be indirect,for example by altering nuclear histones which can lead to changes in gene transcription (Rishal and Fainzilber,2014).All of these mechanisms come into play in developing axons as calcium is required for both axon pathfinding and branching.Furthermore,after neuronal injury,waves of calcium originating at the site of axon segmentation and propagating to the nucleus have long been known to be required for regeneration (Rishal and Fainzilber,2014).These changes in intracellular calcium concentrations [Ca2+]imust be properly controlled or else new growth cones may fail to form and degeneration of the neuron may occur.While many of the molecular players involved in these calcium-dependent processes have been identified,calcium buffering proteins have often been undervalued for their role in regulating axon growth either during normal development or in the event of injury.
机标关键词：synaptic transmissionintracellular calciumsecond messengerneuronal injuryion channels
论文发表日期：2016-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 208-209 )
英文信息