Tissue-type plasminogen activator is a modulator of the synaptic vesicle cycle
Manuel Yepes
摘要：Tissue-type plasminogen activator (tPA) is a serine proteinase that catalyzes the conversion of plasminogen into plasmin.For a long time after its discovery it was thought that tPA's main source was the endothelial cell and that therefore its chief role was to generate plasmin in the vascular system.However,this concept was challenged four decades later when a group of investigators detected tPA mRNA in well-defined areas of the brain,namely the hippocampus,hipothalamus,thalamus,neocortex and cerebellum;and tPA-catalyzed proteolysis in the hippocampus,the amygdala,the thalamus and the hypothalamus (Sappino et al.,1993).Remarkably,subsequent work indicated that neurons but not endothelial cells are the main reservoir of tPA in the central nervous system,and that in the brain tPA has many functions that do not require plasminogen as a substrate (Yepes et al.,2003).Interestingly,while most of the studies on neuronal tPA have been performed either with cells cultured from the hippocampus or with hippocampal slices,fewer have investigated whether tPA has a function in cerebral cortical neurons (Wu et al.,2012,2015).
机标关键词：central nervous systemplasminogen activatorendothelial cellsvascular system
论文发表日期：2016-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 212-213 )
英文信息