Gas6-Tyro3 signaling is required for Schwann cell myelination and possible remyelination
Tomohiro Torii
Junji Yamauchi
摘要：Myelin plays important roles in vertebrates,ensuring the rapid propagation of action potentials and the long-term integrity of axons,but the molecular mechanisms of myelin formation remain poorly understood.Recent studies have demonstrated that myelination is regulated by the TYRO3,AXL (also known as UFO) and MERTK (TAM) family of enzymes,which consists of Tyro3 (also known as Brt,Dtk,Rse,Sky,and Tif),Axl (also known as Ark,Tyro7,and Ufo),and Mer (also known as Eyk,Nym,and Tyro12) along with its ligand growth arrest-specific gene 6 (Gas6) (Binder et al.,2011;Tsiperson et al.,2011;Miyamoto et al.,2015).The three TAMs are also expressed in the brain during postnatal development,specifically,in the white matter,which consists of myelinated axons (Prieto et al.,2000).These studies are helping to identify the signals that are associated with myelination in oligodendrocytes and Schwann cells.
机标关键词：postnatal developmentmolecular mechanismsrapid propagationaction potentialsSchwann cells
论文发表日期：2016-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 215-216 )
英文信息