New insight into curcumin-based therapy in spinal cord injuries: CISD2 regulation
Chai-Ching Lin
Muh-Shi Lin
摘要：Multiple protective effects of curcumin in cases of spinal cord injuries (SCIs):Curcumin [1,7-bis(4-hydroxy-3-methoxy-phenyl)-1,6-heptadiene-3,5-dione] is a nonsteroidal,naturally occurring compound commonly utilized as a dietary pigment as well as a spice in India.It is obtained from curcuma longa in the Ginger family.Due to its anti-inflammatory,anti-oxidant,and immunomodulatory activities,this extract has been used to treat a number of inflammatory and neurodegenerative conditions,including Alzheimer's disease,multiple sclerosis,and trauma to the central nervous system (Menon and Sudheer,2007).Curcumin antagonizes several processes involved in the inflammatory cascade,including the activation of nuclear factor kappa B (NF-κB) and inducible nitric oxide synthase (iNOS)(Weber et al.,2006).It has also been shown to scavenge NO,decrease lipid peroxidation,and attenuate mitochondrial dysfunction (Wang et al.,2005).
机标关键词：mitochondrial dysfunctionnuclear factor kappa Bcentral nervous systemnitric oxide synthasespinal cord injuriesprotective effectslipid peroxidationcurcuma longa
资助基金：grants from the Taipei Institute of Pathology,Taiwan(TIP10102A)the Taipei City Hospital,Taiwan(TPCH-102-061 and TPCH-104-043)the Department of Health,Taipei City Government(10401-62-038)
论文发表日期：2016-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 222-223 )
英文信息