Endoproteolytic cleavage as a molecular switch regulating and diversifying prion protein function
Cathryn L.Haigh
Steven J.Collins
摘要：The prion protein (PrP),through misfolding,is widely known for its causative role in prion diseases,which are transmissible neurodegenerative diseases of humans and animals.There is still no defined function assigned to PrP,especially in the central nervous system,despite many studies in this area.Proposed functions are protean and include signal transduction,neuroprotection,neurogenesis,neuritogenesis,metal-ion homeostasis,memory formation and consolidation,as well as circadian rhythms (Nicolas et al.,2009).Part of the difficulty in assigning a specific function to PrP could perhaps be that it does not have one single function.Instead it might be able to perform many functions and influence various pathways depending upon contextual post-translational modification.
机标关键词：prion proteinneurodegenerative diseasescentral nervous systemsignal transduction
论文发表日期：2016-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 238-239 )
英文信息