The choroid plexus-cerebrospinal lfuid interface in Alzheimer’s disease：more than just a barrier
Sriram Balusu
Marjana Brkic
Claude Libert
Roosmarijn E Vandenbroucke
摘要：The choroid plexus is a complex structure which hangs inside the ventricles of the brain and consists mainly of choroid plexus epithelial (CPE) cells surrounding fenestrated capillaries. These CPE cells not only form an anatomical barrier, called the blood-cerebrospinal lfuid barrier (BCSFB), but also present an active interface between blood and cerebrospinal lfuid (CSF). CPE cells perform indispensable functions for the development, maintenance and functioning of the brain. Indeed, the primary role of the choroid plexus in the brain is to maintain homeostasis by secreting CSF which contains different molecules, such as nutrients, neurotrophins, and growth factors, as well as by clearing toxic and undesirable molecules from CSF. The choroid plexus also acts as a selective entry gate for leukocytes into the brain. Recent ifndings have revealed distinct changes in CPE cells that are associated with aging and Alzheimer’s disease. In this review, we review some recent ifndings that highlight the importance of the CPE-CSF system in Alzheimer’s dis-ease and we summarize the recent advances in the regeneration of brain tissue through use of CPE cells as a new therapeutic strategy.
机标关键词：complex structuregrowth factors
资助基金：the Concerted Research Actions (GOA) of Ghent Uni-versity)the Concerted Research Actions ( the Belgian Science Policy(Interuniversity Attraction Pools - IAP7/07)the Ministry of Education, Science and Technological Development of the Republic of Serbia(Grant ON173056)
论文发表日期：2016-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 534-537 )
英文信息