Volume transmission and receptor-receptor interactions in heteroreceptor complexes:understanding the role of new concepts for brain communication
Kjell Fuxe
Dasiel O Borroto-Escuela
摘要：The discovery of the central monoamine neurons not only demonstrated novel types of brain stem neu-rons forming global terminal networks all over the brain and the spinal cord, but also to a novel type of communication called volume transmission. It is a major mode of communication in the central nervous system that takes places in the extracellular lfuid and the cerebral spinal lfuid through diffusion and lfow of molecules, like neurotransmitters and extracellular vesicles. The integration of synaptic and volume trans-mission takes place through allosteric receptor-receptor interactions in heteroreceptor complexes. These heterocomplexes represent major integrator centres in the plasma membrane and their protomers act as moonlighting proteins undergoing dynamic changes and their structure and function. In fact, we propose that the molecular bases of learning and memory can be based on the reorganization of multiples homo and heteroreceptor complexes into novel assembles in the post-junctional membranes of synapses.
机标关键词：structure and functioncentral nervous systemlearning and memoryplasma membranedynamic changesspinal cordbrain stemtype of
资助基金：Funding(04X-715)by AFA F?rs?kring (130328)
论文发表日期：2016-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 1220-1223 )
英文信息