Intra-axonal protein synthesis - a new target for neural repair?
Jeffery L Twiss
Ashley L Kalinski
Rahul Sachdeva
John D Houle
摘要：Although initially argued to be a feature of immature neurons with incomplete polarization, there is clear evidence that neurons in the peripheral nervous system retain the capacity for intra-axonal protein synthe-sis well into adulthood. This localized protein synthesis has been shown to contribute to injury signaling and axon regeneration in peripheral nerves. Recent works point to potential for protein synthesis in axons of the vertebrate central nervous system. mRNAs and protein synthesis machinery have now been docu-mented in lamprey, mouse, and rat spinal cord axons. Intra-axonal protein synthesis appears to be activated in adult vertebrate spinal cord axons when they are regeneration-competent. Rat spinal cord axons regen-erating into a peripheral nerve graft contain mRNAs and markers of activated translational machinery. Indeed, levels of some growth-associated mRNAs in these spinal cord axons are comparable to the regen-erating sciatic nerve. Markers of active translation tend to decrease when these axons stop growing, but can be reactivated by a second axotomy. These emerging observations raise the possibility that mRNA transport into and translation within axons could be targeted to facilitate regeneration in both the peripheral and central nervous systems.
机标关键词：protein synthesisspinal cordcentral nervous systemperipheral nerve graftperipheral nervesaxon regenerationsciatic nerve
资助基金：Research in the authors’ laboratories that is related to the topic of this review has been supported by grants from the National Institutes of Health(R01-NS041596 and R01-NS089663 to JLT)Research in the authors’ laboratories that is related to the topic of this review has been supported by grants from the National Institutes of Health( P01-NS055976 to JDH)National Science Foundation(MCB-1020970 to JLT)Department of Defense/Congressionally Mandated Research Program(W81XWH-13-1-0308 to JLT)US-Israel Binational Science Foundation(2011329 to JLT)
论文发表日期：2016-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 1365-1367 )
英文信息