Blood microRNAs as potential diagnostic and prognostic markers in cerebral ischemic injury
Bridget Martinez
Philip V Peplow
摘要：MicroRNAs are a family of small, genome-encoded endogenous RNAs that are transcribed but are not translated into proteins. They serve essential roles in virtually every aspect of brain function, including neurogenesis, neural development, and cellular responses leading to changes in synaptic plasticity. They are also implicated in neurodegeneration and neurological disorders, in responses to hypoxia and ischemia, and in ischemic tolerance induced by ischemic preconditioning. In recent developments, miRNA expres-sion proifling has been examined in stroke, and these studies indicate that miRNAs have emerged as key mediators in ischemic stroke biology. Both increased and decreased miRNA levels may be needed either as prevention or treatment of stroke. Novel approaches are being developed to get miRNA related therapeu-tics into the brain across an intact blood-brain barrier, including chemical modiifcation, use of targeting molecules and methods to disrupt the blood-brain barrier.
机标关键词：ischemic preconditioningneurological disordersischemic strokebrain function
论文发表日期：2016-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 1375-1378 )
英文信息