Cell transplantation for the treatment of spinal cord injury- bone marrow stromal cells and choroid plexus epithelial cells
Chizuka Ide
Norihiko Nakano
Kenji Kanekiyo
摘要：Transplantation of bone marrow stromal cells (BMSCs) enhanced the outgrowth of regenerating axons and promoted locomotor improvements of rats with spinal cord injury (SCI). BMSCs did not survive long-term, disappearing from the spinal cord within 2–3 weeks after transplantation. Astrocyte-devoid areas, in which no astrocytes or oligodendrocytes were found, formed at the epicenter of the lesion. It was remarkable that numerous regenerating axons extended through such astrocyte-devoid areas. Regenerating axons were associated with Schwann cells embedded in extracellular matrices. Transplantation of choroid plexus epithelial cells (CPECs) also enhanced axonal regeneration and locomotor improvements in rats with SCI. Although CPECs disappeared from the spinal cord shortly after transplantation, an extensive outgrowth of regenerating axons occurred through astrocyte-devoid areas, as in the case of BMSC transplantation. These ifndings suggest that BMSCs and CPECs secret neurotrophic factors that promote tissue repair of the spinal cord, including axonal regeneration and reduced cavity formation. This means that transplantation of BMSCs and CPECs promotes “intrinsic” ability of the spinal cord to regenerate. The treatment to stimu-late the intrinsic regeneration ability of the spinal cord is the safest method of clinical application for SCI. It should be emphasized that the generally anticipated long-term survival, proliferation and differentiation of transplanted cells are not necessarily desirable from the clinical point of view of safety.
机标关键词：epithelial cellsbone marrow stromal cellsspinal cord injuryaxonal regenerationextracellular matricesneurotrophic factorsclinical applicationcavity formation
资助基金：This work was supported in part by grants from the Japanese Ministry of Education, Culture, Sports, Science, and Technology (2300125 to CI)This work was supported in part by grants from the Japanese Ministry of Education, Culture, Sports, Science, and Technology ( 15K10957 to NN)This work was supported in part by grants from the Japanese Ministry of Education, Culture, Sports, Science, and Technology ( and 26870744 to KK)
论文发表日期：2016-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 1385-1388 )
英文信息