Methods for the analysis of neuronal plasticity and brain connectivity during neurological recovery
Eduardo H.Sanchez-Mendoza
Tayana Silva de Carvalho
Dirk M.Hermann
摘要：The study of neuronal plasticity under pathological conditions is now a major point of focus on the ifeld of neurological recovery. Atfer the repeated failure of acute neuroprotection strategies for stroke treatment, the design of studies aimed at promoting the reconstruction of neuronal networks has become essential. Methods for the delivery of therapeutic agents on a steady dosage, thus preventing pharmacological peaks or excessive manipulation of experimental animals, are thus required. Additionally, methods that allow the visualization of neurological remodeling processes are fundamental to the understanding of how a thera-peutic agent exerts its function. Here we describe how the use of miniosmotic pumps for the steady delivery of such agents, together with tract tracer injections, can be combined to unveil important information on how the brain changes atfer stroke and how therapeutic agents promote brain remodeling recovery.
机标关键词：therapeutic agentsexperimental animalsneuronal plasticity
资助基金：the German Research Council(HE3173/3-1)
论文发表日期：2016-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 1701-1703 )
英文信息