Targeting neuronal nitric oxide synthase as a valuable strategy for the therapy of neurological disorders
Cristina Maccallini
Rosa Amoroso
摘要：The management of neurological disorders have huge and increasing human and economic costs. De-spite this, there is a scarcity of effective therapeutics, and there is an extreme urgency for new and real treatments. In this short review we analyze some promising advancements in the search of new bioactive molecules targeting neuronal nitric oxide synthase (nNOS), an enzyme deputed to the biosynthesis of nitric oxide (NO). In different conditions of neuronal damages, this molecule is overproduced, contribut-ing to the pathogenesis and progression of neuronal diseases. Two main approaches to modulate nNOS are discussed: a ifrst one consisting in the direct inhibition of the enzyme by means of small organic molecules, which can be also active against other different targets involved in such diseases. A second section is dedi-cated to molecules able to prevent the formation of the ternary complex N-methyl-D-aspartate (NMDA)-type glutamate receptors, postsynaptic density-95 (PSD95) protein-nNOS, which is necessary to activate the latter for the biosynthesis of NO.
机标关键词：neurological disordersneuronal nitric oxide synthaseglutamate receptorsternary complex
论文发表日期：2016-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 1731-1734 )
英文信息