Focusing on caveolin-1 in CNS autoimmune disease: multiple sclerosis
Hao Wu
Jiangang Shen
摘要：Multiple sclerosis (MS) is the leading autoimmune disorder in the central nervous system (CNS) that affects over 2.5 million people globally.Clinically,the disease is characterized with severe neurological defects and motor disabilities such as paresis and paralysis.Experimental autoimmune encephalomyelitis (EAE) is a well-defined laboratory animal model of MS that mimics key features of disease including aberrant auto-reactive immune activations in the periphery,CNS oriented pathogenic immune infiltrations,the pathological formation of demyelination in the CNS lesions and symptomatic consequences such as motor disabilities (Ontaneda et al.,2012).
机标关键词：central nervous systemkey featuresanimal model
资助基金：GRF grants from Hong Kong Research Grants Council(GRF 17118511)Seed Fund for Basic Research of the University of Hong Kong(201311159015)
论文发表日期：2016-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1920-1921 )
英文信息