Not only a bad guy: potential proneurogenic role of the RAGE/NF-κB axis in Alzheimer's disease brain
Valeria Bortolotto
Mariagrazia Grilli
摘要：The receptor for advanced glycation endproducts (RAGE) is a receptor of the immunoglobulin superfamily of cell surface molecules which plays important contributions under both physiological and pathological conditions.Over the years extensive research work supported the detrimental role of RAGE in Alzheimer's disease (AD) pathophysiology,ranging from its involvement in beta amyloid (Aβ) brain influx and clearance,neurodegeneration,neuroinflammation,and promotion of synaptic dysfunction.Based on such compelling evidence,preclinical and clinical studies have supported the concept that RAGE inhibitors could represent a useful target for AD treatment (Schmidt et al.,2001;Srikanth et al.,2011).
机标关键词：advanced glycation endproductsresearch work
论文发表日期：2016-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1924-1925 )
英文信息