Blood microRNAs as potential diagnostic markers for hemorrhagic stroke
Bridget Martinez
Philip V Peplow
摘要：Proper medical treatment of a stroke victim relies on accurate and rapid differentiation between ischemic and hemorrhagic stroke, which in current practice is performed by computerized tomography (CT) or magnetic resonance imaging (MRI) scans. A panel of microRNAs could be an extremely useful clinical tool for distinguishing between hemorrhagic and ischemic stroke. hTis review has shown that blood miRNA proifle can distinguish hemorrhagic from ischemic stroke in patients and in experimental animal models. It also seems likely they can differentiate between intracerebral and subarachnoid hemorrhage stroke. hTe miRNA proifle in cerebrospinal lfuid could be a useful diagnostic tool for subarachnoid hemorrhagic stroke. Decreased or increased miRNA levels may be needed either as prevention or treatment of stroke. Administration in vivo of miR-130a inhibitor or miRNA mimic (miR-367, miR-223) in an intracerebral hemorrhage animal model improved neurological outcomes.
机标关键词：hemorrhagic strokeischemic strokemagnetic resonance imagingintracerebral hemorrhagesubarachnoid hemorrhagecomputerized tomographymedical treatmentdiagnostic tool
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 13-18 )
英文信息