Restoring axonal localization and transport of transmembrane receptors to promote repair within the injured CNS:a critical step in CNS regeneration
Lindsey H Forbes
Melissa R Andrews
摘要：Each neuronal subtype is distinct in how it develops, responds to environmental cues, and whether it is capable of mounting a regenerative response following injury. Although the adult central nervous system (CNS) does not regenerate, several experimental interventions have been trialled with successful albeit lim-ited instances of axonal repair. We highlight here some of these approaches including extracellular matrix (ECM) modiifcation, cellular gratfing, gene therapy-induced replacement of proteins, as well as application of biomaterials. We also review the recent report demonstrating the failure of axonal localization and trans-port of growth-promoting receptors within certain classes of mature neurons. More speciifcally, we discuss an inability of integrin receptors to localize within the axonal compartment of mature motor neurons such as in the corticospinal and rubrospinal tracts, whereas in immature neurons of those pathways and in mature sensory tracts such as in the optic nerve and dorsal column pathways these receptors readily local-ize within axons. Furthermore we assert that this failure of axonal localization contributes to the intrinsic inability of axonal regeneration. We conclude by highlighting the necessity for both combined therapies as well as a targeted approach speciifc to both age and neuronal subtype will be required to induce substantial CNS repair.
机标关键词：central nervous systemextracellular matrixaxonal regenerationmotor neuronsoptic nerve
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 27-30 )
英文信息