Endoplasmic reticulum-mitochondrial crosstalk:a novel role for the mitochondrial peptide humanin
Parameswaran G Sreekumar
David R Hinton
Ram Kannan
摘要：In this review, the interactive mechanisms of mitochondria with the endoplasmic reticulum (ER) are dis-cussed with emphasis on the potential protective role of the mitochondria derived peptide humanin (HN) in ER stress. hTe ER and mitochondria are dynamic organelles capable of modifying their structure and function in response to changing environmental conditions. The ER and mitochondria join together at multiple sites and form mitochondria-ER associated membranes that participate in signal transduction pathways that are under active investigation. Our laboratory previously showed that HN protects cells from oxidative stress induced cell death and more recently, described the beneifcial role of HN on ER stress-in-duced apoptosis in retinal pigment epithelium cells and the involvement of ER-mitochondrial cross-talk in cellular protection. hTe protection was achieved, in part, by the restoration of mitochondrial glutathione that was depleted by ER stress. hTus, HN may be a promising candidate for therapy for diseases that involve both oxidative and ER stress. Developing novel approaches for retinal delivery of HN, its analogues as well as small molecular weight ER stress inhibitors would prove to be a valuable approach in the treatment of age-related macular degeneration.
机标关键词：ER stressretinal pigment epitheliumenvironmental conditionsstructure and functionendoplasmic reticulummacular degenerationsignal transductionoxidative stress
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 35-38 )
英文信息