Platelet-rich plasma, an adjuvant biological therapy to assist peripheral nerve repair
Mikel Snchez
Ane Garate
Diego Delgado
Sabino Padilla
摘要：hTerapies such as direct tension-free microsurgical repair or transplantation of a nerve autogratf, are now-adays used to treat traumatic peripheral nerve injuries (PNI), focused on the enhancement of the intrinsic regenerative potential of injured axons. However, these therapies fail to recreate the suitable cellular and molecular microenvironment of peripheral nerve repair and in some cases, the functional recovery of nerve injuries is incomplete. hTus, new biomedical engineering strategies based on tissue engineering approach-es through molecular intervention and scaffolding offer promising outcomes on the field. In this sense, evidence is accumulating in both, preclinical and clinical settings, indicating that platelet-rich plasma products, and ifbrin scaffold obtained from this technology, hold an important therapeutic potential as a neuroprotective, neurogenic and neuroinlfammatory therapeutic modulator system, as well as enhancing the sensory and motor functional nerve muscle unit recovery.
机标关键词：nerve repairperipheral nervebiomedical engineeringtherapeutic potentialtissue engineering
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 47-52 )
英文信息