Current view and perspectives in amyotrophic lateral sclerosis
Stphane Mathis
Philippe Couratier
Adrien Julian
Philippe Corcia
Gwendal Le Masson
摘要：Amyotrophic lateral sclerosis (ALS), identiifed as a distinct clinical entity by Charcot since the end of the nineteenth century, is a devastating and fatal neurodegenerative disorder that affects motor neurons in the brain, brainstem and spinal cord. Survival of patients with ALS is associated with several factors such as clinical phenotype, age at onset, gender, early presence of respiratory failure, weight loss and treatment with Riluzole (the only disease-modifying drug approved for this disease). Nowadays, there is still no cu-rative treatment for ALS: palliative care and symptomatic treatment are therefore essential components in the management of these patients. Nevertheless, the scientiifc knowledge in the ifeld of ALS motor neuron degeneration is growing, with the prospect of new treatments. Based on this physiopathological knowledge, several new therapeutic targets are being studied, involving various mechanisms such as excitotoxicity, neuroinflammation, mitochondrial dysfunction, oxidative stress, RNA metabolism and other attractive concepts. Moreover, it is also important to identify reliable biomarkers that will be essential components for future therapeutic development and study design in ALS. In this review, we present the main recent ad-vances and promising therapeutics and biomarkers in the ifeld of ALS.
机标关键词：neurodegenerative disorderrespiratory failureclinical phenotypemotor neuronsspinal cord
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 181-184 )
英文信息