Pretreated quercetin protects gerbil hippocampal CA1 pyramidal neurons from transient cerebral ischemic injury by increasing the expression of antioxidant enzymes
Bai Hui Chen
Joon Ha Park
JiHyeon Ahn
JeongHwi Cho
In Hye Kim
Jae Chul Lee
Moo-Ho Won
Choong-Hyun Lee
In Koo Hwang
Jong-Dai Kim
Il Jun Kang
Jun Hwi Cho
Bich Na Shin
Yang Hee Kim
Yun Lyul Lee
Seung Min Park
摘要：Quercetin (QE; 3,5,7,3′,4′-pentahydroxyflavone), a well-known flavonoid, has been shown to prevent against neurodegenerative disorders and ischemic insults. However, few studies are reported regarding the neuroprotective mechanisms of QE atfer ischemic insults. hTerefore, in this study, we investigated the effects of QE on ischemic injury and the expression of antioxidant enzymes in the hippocampal CA1 region of gerbils subjected to 5 minutes of transient cerebral ischemia. QE was pre-treated once daily for 15 days before ischemia. Pretreatment with QE protected hippocampal CA1 pyramidal neurons from ischemic injury, which was confirmed by neuronal nuclear antigen immunohistochemistry and Fluoro-Jade B histolfuorescence staining. In addition, pretreatment with QE signiifcantly increased the expression levels of endogenous antioxidant enzymes Cu/Zn superoxide dismutase, Mn superoxide dismutase, catalase and glutathione peroxidase in the hippocampal CA1 pyramidal neurons of animals with ischemic injury. hTese ifndings demonstrate that pretreated QE displayed strong neuroprotective effects against transient cerebral ischemia by increasing the expression of antioxidant enzymes.
机标关键词：antioxidant enzymestransient cerebral ischemiasuperoxide dismutaseneurodegenerative disordersneuroprotective effectsglutathione peroxidase
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 220-227 )
英文信息