3′-Daidzein sulfonate sodium improves mitochondrial functions atfer cerebral ischemia/reperfusion injury
Wa Yuan
Qin Chen
Jing Zeng
Hai Xiao
Zhi-hua Huang
Xiao Li
Qiong Lei
摘要：3′-Daidzein sulfonate sodium is a new synthetic water-soluble compound derived from daidzein (an active ingredient of the kudzu vine root). It has been shown to have a protective effect on cerebral ischemia/reperfusion injury in rats. We plan to study the mechanism of its protective effect. 3′-Daidzein sulfonate sodium was injected in rats atfer cerebral ischemia/reperfusion injury. Results showed that 3′-daidzein sulfonate sodium signiifcantly reduced mitochondrial swelling, signiifcantly elevated the mitochondrial membrane potential, increased mi-tochondrial superoxide dismutase and glutathione peroxidase activities, and decreased mitochondrial malondialdehyde levels. 3′-Daidzein sulfonate sodium improved the structural integrity of the blood-brain barrier and reduced blood-brain barrier permeability. hTese ifndings conifrmed that 3′-daidzein sulfonate sodium has a protective effect on mitochondrial functions atfer cerebral ischemia/reperfusion injury, improves brain energy metabolism, and provides protection against blood-brain barrier damage.
机标关键词：protective effectcerebral ischemiaglutathione peroxidasesuperoxide dismutasestructural integrityprotection againstmembrane potentialenergy metabolism
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 235-241 )
英文信息