DCDC2 gene polymorphisms are associated with developmental dyslexia in Chinese Uyghur children

Yun Chen; Hua Zhao; Yi-xin Zhang; Peng-xiang Zuo

doi:10.4103/1673-5374.200809

摘要：Developmental dyslexia is a complex reading and writing disorder with strong genetic components. In previous genetic studies about dys-lexia, a number of candidate genes have been identiifed. hTese include DCDC2, which has repeatedly been associated with developmental dyslexia in various European and American populations. However, data regarding this relationship are varied according to population. hTe Uyghur people of China represent a Eurasian population with an interesting genetic proifle. hTus, this group may provide useful informa-tion about the association between DCDC2 gene polymorphisms and dyslexia. In the current study, we examined genetic data from 392 Uyghur children aged 8–12 years old from the Xinjiang Uyghur Autonomous Region of China. Participants included 196 children with dyslexia and 196 grade-, age-, and gender-matched controls. DNA was isolated from oral mucosal cell samples and fourteen single nucle-otide polymorphisms (rs6456593, rs1419228, rs34647318, rs9467075, rs793862, rs9295619, rs807701, rs807724, rs2274305, rs7765678, rs4599626, rs6922023, rs3765502, and rs1087266) in DCDC2 were screenedvia the SNPscan method. We compared SNP frequencies in ifve models (Codominant, Dominant, Recessive, Heterozygote advantage, and Allele) between the two groups by means of the chi-squared test. A single-locus analysis indicated that, with regard to the allele frequency of these polymorphisms, three SNPs (rs807724, rs2274305, and rs4599626) were associated with dyslexia. rs9467075 and rs2274305 displayed signiifcant associations with developmental dyslexia under the dominant model. rs6456593 and rs6922023 were signiifcantly associated with developmental dyslexia under the dominant model and in the heterozygous genotype. Additionally, we discovered that the T-G-C-T of the four-marker haplotype (rs9295619-rs807701-rs807724-rs2274305) and the T-A of the two-marker haplotype (rs3765502-1087266) were significantly different between cases and controls. hTus, we conclude that DCDC2 gene polymorphisms are associated with developmental dyslexia in Chinese Uyghur children.