Small regulators making big impacts:regulation of neural stem cells by small non-coding RNAs
Zhong Liu
Rui Zhao
摘要：Neurodegeneration and traumatic brain injuries are leading caus-es of disability and present an enormous disease burden both in terms of patient suffering and healthcare cost. Treatment of brain lesions remains as a major challenge in medicine largely because of the limited regenerative capacity of the adult brain. Neural stem cells (NSCs), which are present in the embryonic nervous system and in specific regions of the adult brain, have the capacity for self-renewal by making identical daughter NSCs, and for differ-entiation into all neural cell types including neurons, astrocytes, and oligodendrocytes, therefore represent a promising therapeu-tic cellular source to treat brain lesions (Gage and Temple, 2013). However, NSCs are susceptible to genotoxic insults because of their proliferative nature, which could lead to unregulated NSC proliferation and brain tumors (Vescovi et al., 2006).
机标关键词：nervous systembrain injuriesbrain tumorsstem cells
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 397-398 )