Targeting colony stimulating factor 1 receptor to prevent cognitive deficits induced by fractionated whole-brain irradiation
Xi Feng
Susanna Rosi
摘要：Whole-brain irradiation (WBI), usually delivered in 25–30 fractions to accumulate a total dose of 55–60 Gy, is common-ly used for the treatment of primary tumors in the central nervous system (CNS) and brain metastases. With improved treatment techniques patients have prolonged overall survival, but are more likely to experience late adverse effects. In con-trast to other symptoms that concur with treatment, cognitive impairments develop in 50–90% of long term survivors (> 6 months) after WBI and are often progressive and irreversible (Greene-Schloesser and Robbins, 2012). The mechanisms re-sponsible for the progressive cognitive impairments are poorly understood, and there is no clinical treatment to prevent or re-duce these adverse effects.
机标关键词：central nervous systemtreatment techniquesclinical treatmentoverall survivalbrain metastases
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 399-400 )