Neurotrophic factors in Alzheimer's and Parkinson's diseases: implications for pathogenesis and therapy
Tuane Bazanella Sampaio
Anne Suely Savall
Maria Eduarda Ziani Gutierrez
Simone Pinton
摘要：Neurotrophic factors comprise essential secreted proteins that have several functions in neural and non-neural tissues, mediating the development, survival and maintenance of peripheral and central nervous system. Therefore, neurotrophic factor issue has been extensively investigated into the context of neurodegenerative diseases. Alzheimer's disease and Parkinson's disease show changes in the regulation of specific neurotrophic factors and their receptors, which appear to be critical for neuronal degeneration. Indeed, neurotrophic factors prevent cell death in degenerative processes and can enhance the growth and function of affected neurons in these disorders. Based on recent reports, this review discusses the main findings related to the neurotrophic factor support – mainly brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor – in the survival, proliferation and maturation of affected neurons in Alzheimer's disease and Parkinson's disease as well as their putative application as new therapeutic approach for these diseases management.
机标关键词：neurotrophic factorsneurodegenerative diseasescentral nervous systemneuronal degenerationsecreted proteinsthe growthglial cellcell death
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 549-557 )
英文信息