Endothelial progenitor cells as a therapeutic option in intracerebral hemorrhage
Juan Pías-Peleteiro
Francisco Campos
José Castillo
Tomás Sobrino
摘要：Intracerebral hemorrhage (ICH) is the most severe cerebrovascular disease, which represents a leading cause of death and disability in developed countries. However, therapeutic options are limited, so is mandatory to investigate repairing processes after stroke in order to develop new therapeutic strategies able to promote brain repair processes. Therapeutic angiogenesis and vasculogenesis hold promise to improve outcome of ICH patients. In this regard, circulating endothelial progenitor cells (EPCs) have recently been suggested to be a marker of vascular risk and endothelial function. Moreover, EPC levels have been associated with good neurological and functional outcome as well as reduced residual hematoma volume in ICH patients. Finally, experimental and clinical studies indicate that EPC might mediate endothelial cell regeneration and neovascularization. Therefore, EPC-based therapy could be an excellent therapeutic option in ICH. In this mini-review, we discuss the present status of knowledge about the possible therapeutic role of EPCs in ICH, molecular mechanisms, and the future perspectives and strategies for their use in clinical practice.
机标关键词：intracerebral hemorrhagecerebrovascular diseaseendothelial functionclinical practiceprogenitor cellsendothelial cellpresent statuscause of death
资助基金：This study has been partially supported by grants from the Spanish Ministry of Economy and Competitiveness(SAF2014-56336)the Instituto de Salud Carlos III(PI13/00292 & PI14/01879)the Spanish Research Network on Cerebrovascular Diseases(RETICS INVICTUS)the Spanish Research Network on Cerebrovascular Diseases(RD12/0014)the Xunta de Galicia(Department of Education)the Xunta de Galicia( GRC2014/027)the European Union program FEDER. Furthermore, F. Campos(CP14/00154)TS (CP12/03121)
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 558-561 )
英文信息